https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4425 Wed 11 Apr 2018 13:44:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17727 − ion conductance). Pharmacological analyses in vitro and in vivo determined that elevated Cl⁻ conductance is mediated by altered cystic fibrosis transmembrane conductance regulator expression and activity. Generation of iIL-13Tg/Il13rα1^−/−, iIL-13Tg/Il13rα2^−/−, and iIL-13Tg/Stat6^−/− mice revealed that IL-13-mediated dysregulation of epithelial architecture and Cl⁻ conductance is dependent on IL-13Rα1 and STAT-6. These observations demonstrate a central role for the IL-13/IL-13Rα1 pathway in the regulation of intestinal epithelial cell Cl⁻ secretion via up-regulation of cystic fibrosis transmembrane conductance regulator, suggesting an important role for this pathway in secretory diarrhea.]]> Sat 24 Mar 2018 07:57:45 AEDT ]]>